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Two recent studies that included individuals with and without type 2 diabetes found that GLP-1 contributed ~50% of the glucose-lowering and insulin-stimulatory effects of DPP-4 inhibitors [2, 18]

Most GLP-1 receptor agonists carry a boxed warning for thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

GLP-1 also helps regulate blood sugar levels by stimulating the release of insulin after meals, which can reduce the risk of insulin resistance and metabolic issues

However, SREBP2, a protein related to cholesterol metabolism, remained unaffected (Fig